. The design and results of the Mayo Chest X-Ray Trial.
. International Early Lung CA Project: 1-arm trial [low-dose CT ].
. (US) National Lung Screening Trial [low-dose CT ]
Links
Mammographic screening: no reliable supporting evidence?
Substantive article Technical article Combined
Hanley JA
Analysis of Mortality Data From Cancer Screening Studies: Looking in the Right Window
Epidemiology, Vol 16, No. 6, November 2005, pp 786-790
Hanley JA
Mortality reductions produced by sustained prostate cancer screening have
been underestimated
Supplementary Material
Journal of Medical Screening (2010), 17(3) 147-151.
2010.04.09: CANNeCTIN Biostat. Methodology Videoconference
slides
video
2010.05.26 Annual Meeting of Statistical Society of Canada, Quebec City
Underestimation of Mortality Reductions in
Cancer Screening Studies: The ERSPC as a Case Study
Hanley JA Measuring mortality reductions in cancer screening trials.
Epidemiologic Reviews, 2011. Theme Issue on Screening
Abstract
PDF
WebFigures/Table
International Early Lung Cancer Action Program, Scottsdale, Arizona
Underestimation of Mortality Reductions in Cancer Screening Studies:
Prostate, Breast, Colon and [???] Lung (by Video)
Video(.wmv, 228MB, wait for it to dwnload&play)
slides, for printing
for on screen viewing
To Canadian Institutes of Health Research, March 1, 2011
- Reviews / Recommendation
How Big Are The Mortality Reductions Produced by Cancer Screening? Why do so many trials say 20%?
2011.08.24: International Society of Clinical Biostatistics.
How big are the mortality reductions produced by cancer Screening?
Why do so many trials say only 20%?
pdf
2012.03.08: Up Close (Interview) University of Melbourne
link to transcript and podcast
Auckland, Sydney, Melbourne, and
Seattle ,
Feb-May 2012
Hanley JA, Liu Z, McGregor M. p800 in Letters re UK Panel report
on The benefits and harms of breast cancer screening.
www.thelancet.com Vol381 March9,2013
Annual Meeting, Statistical Society of Canada, Edmonton, Alberta
The mortality reduction patterns produced by cancer screening:
Models/simulations/animations to study mortality patterns in cancer screening
2013.08.07: Joint Statistical Meetings, Montreal, Canada
How big are the mortality reductions produced by cancer Screening?
Why do so many trials say only 20%? pdf
Liu Z, Hanley JA and Strumpf EC.
Projecting the yearly mortality reductions due to a cancer screening programme
J Med Screen 20(3) 157-164 (2013)
Hanley JA, McGregor M, Liu Z, Strumpf EC, Dendukuri N.
Measuring the Mortality Impact of Breast Cancer Screening
Can J Public Health 2013;104(7):e437-e442.
Liu Z (A), Hanley JA , Saarela O and Dendukuri N
A Conditional Approach to Measure Mortality Reductions Due to Cancer Screening
International Statistical Review (2015), 0, 0, 1-18 doi:10.1111/insr.12088
Liu Z(A). Measuring Mortality Reductions Due to Cancer Screening
oral presentation
thesis
to ERSPC C'tee
2. Presentation (.pdf)
James Hanley
Zhihui (Amy) Liu 
- Introduction (JH) .mov format .avi format *
- Background (JH) .mov format .avi format *
- Methods (AL) .mov format .avi format *
- Application: 2 case studies (AL) .mov format .avi format *
- ERSPC data (JH) .mov format .avi format *
* may need to download file, THEN open with an application e.g. VLC
- Spreadsheet template for ERSPC data (JH) .mov format .avi format
Weedon-Fekjaer, H. BMJ paper (and 2010 NEJM paper by others) on using
Norwegian population-based data to evaluate impact of organized mammography
BMJ and NEJM papers
James Hanley, Zhihui (Amy) Liu, Nandini Dendukuri, Erin Strumpf
51st Annual ANDRÉ AISENSTADT MEMORIAL CLINICAL DAY CANCER SCREENING – UPDATE 2014
How much does screening reduce cancer mortality?
Harald Weedon-Fekjaer (Norwegian University of Science and Technology, Trondheim; and University of Oslo, Norway)
visited us at McGill December 8-12, and presented a seminar on his work.
Hanley JA, Weedon-Fekjaer H, Hannigan A, Saarela O.
Population data to measure mortality reductions produced by organized cancer
screening: analyze with care
Program
Abstract
Presentation
Jacobs, Menon, ... , Skates
UK Trial of Ovarian Cancer Screening [The Lancet]
Empirical hazard function fitted to data in Fig. 2 of the Lancet article
R code to make the HR plot
(c.f. 2017 ICSN poster)
James A. Hanley, Zhihui (Amy) Liu, Olli Saarela
Fitting a Model of the Mortality Reductions Produced by One/Several Rounds of Cancer Screening:
Time and Sample Size Considerations
James A. Hanley, Sisse H. Njor
Estimating the mortality
reduction produced by each round of cancer screening
James A. Hanley, Sisse H. Njor { POSTER }
Estimating the mortality
reduction produced by each round of cancer screening
Lower-Resolution version
James A. Hanley, Ailish Hannigan , Katie M. O'Brien.
Hanley JA and Njor SH.
Hanley JA
Hanley JA
Hanley JA
Hanley JA
Hanley JA et al.
International Cancer Screening Network Conference 2019:
Hanley JA et al.
Hanley J
Hanley JA * Java (1)
play * Java (2) frames/second:
2
25
screenshot
or ... movie * MotionChart generated in R by googleVis
change speed in app * R animation package
change speed in app
Hanley JA, Deck W, Kochoedo M.
Wilber Deck, James Hanley
Wilber Deck, James Hanley
Mortality reductions due to mammography screening:
Contemporary population-based data.
PLOS ONE. 2017.
2017 Invitee
2018 Eur J Epi
Disaggregating the mortality reductions
due to cancer screening: model-based
estimates from population-based data.
European J. Epidemiology. 2017.
Commentary
2018 ARCC
The mortality reductions produced by cancer screening:
Why do published results vary so much?
Slides shown at Panel Discussion. Conference: Applied Research on Cancer Control
Montreal, Quebec 2018-05-28
2019 Duke U
Measuring the mortality reductions produced by organized cancer screening: a principled approach
Seminar, Dept of Biostatistics and Bioinformatics, 2019-02-01
2019 NCI(US)
Measuring the mortality reductions produced by organized cancer screening: a principled approach
Presentation to Precision Prevention and Screening Group. Biostatistics Branch, Division of Cancer Epidemiology & Genetics, 2019-02-19 [1pm-3pm]
2019 NCI(US)
Intro (video) ..
Measuring the mortality reductions produced by organized cancer screening:
Why do published results vary so much? (Video)
Division of Cancer Epidemiology & Genetics, 2019-02-20
[delivered offsite, since snowstorm closed federal agencies]
2019 CASI(Ireland)
Measuring the mortality reductions produced by Irish and Danish breast-cancer
screening programs.
Slides
Lyrics
2019 ICSN
Screening in balance (Rotterdam, June 3-5)
Program
Abstracts (incl. Posters)
2019 Karolinska(Sweden)
Measuring the mortality reductions produced by Irish and Danish breast-cancer
screening programs.
Slides
Lyrics
2019 McGill
Cancer "Screening": Principles, Programs, Performance:
Seminar Announcement
Slides
Lyrics
Vocals
2020 NCI(US)
Measuring the mortality reductions produced by organized cancer screening: a principled approach
Biostatistics Branch Seminar Series, 2020-01-14
Animation
Animation
Animation
Animation
2019
Communication
James Hanley's
"Suggestions regarding the analysis of the UKCTOCS data".
JH was one of the "12 experts in statistics/epidemiology/screening trials" whose suggestions were solicited and summaried in the 2021 Trials
article.
Note that the links referred to in the communication can be found above.
2021 Trials
UKCTOCS update: applying insights of delayed effects in cancer screening trials to the long-term follow-up mortality analysis
2021
Lancet 2021
Lancet
Reg Health
Eur
Underestimating the lung cancer mortality reductions produced by low-dose CT screening
Lancet Reg Health Eur 2021; 11:
2022 Presentation
Screens per death averted: A less biased estimator of the performance of lung
cancer screening programs
McGill Biostatistics Seminar Series, September 28, 2022.
2023/4
J Med Scr
Deaths averted: An unbiased alternative to rate ratios for measuring the performance of
cancer screening programs
Journal of Medical Screening, Early view 2023, Volume 31 Issue 3, September 2024
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Updated: February 19, 2025.