BIOS601 AGENDA: Monday Oct 17 and Wednesday Oct 19, 2022

Agenda for Monday Oct 17, 2022

The (log-)likelihood, and parameter estimation (C&H Ch 03): scalar and vector parameters

• Material: C&Hs Chapter 03 (Likelihood)
  
  
• JH to present:
  
  5.2 : Estimate sigma of N(0,sigma) from binned data
  5.3 : Estimate mu and sigma of N(mu,sigma) from binned data
  
  
• Answers to be uploaded by end of Fri Nov 21:
  
     3.06 Two datapoints and a model
     3.10 Estimate concentration from dilution series
     3.20 Estimate parameter p in chain-binomial model for measles transmission
  
  

Agenda for Wednesday Oct 19, 2022

The (log-)likelihood for the 'Rate' Parameter (λ); Person-Time; Poisson Model (C&H Ch 05)

• Material: C&Hs Chapter 05 (Rates)
  
  
• JH to present:
  
     5.01 1-parameter model for rate in control arm, Uganda trial of adult circumcision to reduce risk of HIV acquisition
  
  
• Answers to be uploaded by end of Fri Nov Oct 21:
  
     5.03 3-parameter model control arm, Uganda trial
     5.02 Estimate the de novo mutation rate from Iceland 'trios' data
     5.08 Constant-rate model fitted to data from control arm, Kenya trial