Human Experimentation: A Guided Step into the Unknown William A. Silverman Updated: Tuesday June 12, 2007 Titles Preface Contents Chapters 'Knowing' in medicine Framing the question Representative patients Controlled comparison Intervention Accurate observation The event of interest Avoiding entrapment The stopping rule Inferential decision Extrapolation of trial results The ethics of human experimentation Appendix A: The story of retrolental fibroplasia Appendix B: Checklist for randomized clinical trial design Further reading Acknowledgments and citations Index